1. I think romance is fine in this genre. It reminds me of a book we had to read in school, "Flowers for Algernon". The main character was mentally disabled, but he still had romantic relationships. It was important to the story because it showed that the character is/was still human, and he is/was developing/maturing in his own way, and was still trying to live a normal life and have normal relationships. In one of my favorite TV shows "Go On", the characters attend therapy sessions for their depression. They (er, mainly just the main character) has some romance blossom as well. My point is that therapy and/or illnesses don't necessarily have to stop a person from getting into a relationship. But with that being said, I really like that you have made it to where the relationship may or may not help Juliette. =)
3. I like Brandon and James/Junichi, so I'd go for one of them, depending on whose dialogue I like better. =) The last person I'd go for is either Rodney or Leigh (I guess that was kinda obvious). Rodney seems like he's kinda dangerous, so I'd stay away from him for that reason. As for Leigh, *sigh* I just very, very much dislike hipsters and dense people. =P Where I live, hipsters are EVERYWHERE, and I really, really hate it. >.< The thing about dense people though, is that many people just pretend to be dense. I like characters like those, the ones who act like they're stupid, but when the time is right, their intelligence/observation blows you away.
4. I think that's really cool and creative! I played a game awhile back (can't remember the name), in which the player plays as a doctor for various stuffed animals visiting a psychiatric clinic. Based on how well you progress in therapy, the stuffed animals will have memories that are presented as short animated clips. It was really cool, and I'd like to see it in a VN!
5. I think a game like this is great, very original type of story.
6. Personally, I don't actually buy online games. I buy console/PC games, play free browser-based games, or download free games, but that's about it. So...I can't really answer this question...similar to the way I can't answer mine on my own thread. x)
7. Yeah, I'd probably play this game. =) If it's commercial though, it'd depend on the price of the game.

