Start as close to the action as possible. For instance, when the story starts, have the main character already decided that she no longer wants to do corporate espionage or assassinations. In the first scene, she is active, and doing something such as...LukaHastune wrote:... she's a wanted runaway experiment, the government wants to capture her by sending people after her...
* Trying to escape a lab of mad scientists
* Looking for a place to hide
* Attempting to change her appearance
If she has a supernatural ability, that could add some conflict. Let's say she has a superpower that lets her defend herself, or hide in plain sight. The problem is that she only has this power because of the secret agency's experimental surgeries, or because of black magic. She can not be a normal person unless she finds a way to undo this power.
One of my plotbunnies: The main character has grown up in luxury as the heir of a rich family. Then his family introduces him to a girl who is meant to be his bodyguard. He realizes that they raised the girl to be an obedient human weapon, and he finds it horrifying. He wants to leave his family's mansion as soon as possible, and then hide somewhere. There is an active antagonist -- one person in the main character's family wants to keep both of them under his/her control. (The story might benefit from at least one more sympathetic character: a person who was supposed to train the bodyguard girl but helped her become more human, or a family servant who provides the main character with advice. Also, it doesn't matter whether the main character and the bodyguard are male or female.)
Where would the story go from there? It would be about two people who want to escape from their problems for a while. They don't know how to relate to people in the real world, or to each other. They need to deal with the problem of their family trying to take them back, rather than constantly running away.