I'll throw out one...Danganropa...but with adult characters. (Or I suppose Squid Game the Murder Mystery)
16 (or 12 or 20 or whatever) adults with particular skills, who are hard on their luck, are promised a lucrative job by a sinister billionaire. When they arrive, they find they're trapped on an island and can only escape (with prize money) IF they can kill another person and get away with it. If they do, everyone else on the island dies. And if the last two are able to solve all the murders, they escape with an equal share of the prize money.
You could have an intersting cast of characters - think injured athelete, dancer/gymnast/other type who retires early past her prime, homemaker who lost a spouse, struggling artist, disbarred lawyer, etc.
Anyway, curious what other people think would be fun/interesting to play (if it only existed). And who knows? Someone else might be aware that the game you want to play actually *does* exist and provide a recommendation.