Ren'PyWeb or Monogatari Engine?

[Overdose]

Hi there! I'm considering making a web-based Visual Novel sometime in the future. I was wondering, what are the differences between the two?
The pros and cons?

And, an extra question - can you play games built with either of these on the itch.io website? How would a user play them? Sorry if it's a silly question

Thanks and have a nice day!