We all talk about it here alot on the forum, so we should give it a thread!
They're slowly revealing information about the new installment due March 8th, 2011. But here's some stuff we already know:

The main character is now one character, named Hawke. You can play as Garrett Hawke (Male) or Marian Hawke (Female), and they will be fully voiced. So, just like Mass Effect. So, no Origins stories, and you can't play as a Dwarf or Elf. You can choose between Warrior, Mage, and Rogue just like before. They said they reduced it to one possible character to tell a more personal story.
Game should span around ten years of time, and doesn't take place in Ferelden, but a place called the Free Marches where Hawke has become known as the Champion of Kirkwall.
There a few revealed companions already:

Bethany and Carver: They're your siblings, your sister and your brother.

Isabela: The pirate you met in the Pearl in the first game. She got a make-over and is now your saucy companion. She is a confirmed love interest.

Aveline: Warrior woman! Finally!

Varric: Dwarf Merchant Prince with enough body hair to kill a man. His weapon is a crossbow named Bianca.

Fenris: Elf with lyrium tattoos. Big hopes he's a love interest, too (not confirmed yet).

Merrill: "Virginal girl next door" elf mage. I very much remember her from the first game, being the apprentice keeper of the Dalish tribe.

Anders: Apostate mage you met in DA:Awakenings. This time he has glowy eyes and doesn't seem so ... Alistair. But it doesn't matter how evil he looks or pretends to be, he's still the healer.

Sebastian (DLC Only!): Exiled prince looking for revenge on his murdered family. FAMILIAR MUCH?
Flemeth will make an appearance in DA2. Looking badass in her new dominatrix outfit. =P
I'm purposely not saying everything I know, since it's the first post and I hate when stuff is spoiled for me.
NOW LET'S GEEK OUT!
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